This diagram presents a layered, model-driven architecture for semantic, low-code orchestration of industrial IT/OT systems. At its foundation, a core meta layer defines universal abstractions—such as global namespaces, meta data types, inheritance trees, finite state machines, and base objects—which provide formal consistency, extensibility, and internationalization across domains. Building on this, the common domain layer introduces low-code paradigms, workflow DSLs, type mappings, and behavioral models that translate abstract meta-structures into reusable domain-independent constructs. The domain-specific layer further specializes these constructs through scene/world models, domain architectures, and semantic no-code representations tailored to particular industrial contexts. On the execution side, CREEM schemas and instances bridge human-centric representations (natural language, UML/SysML, BPMN) with machine-executable workflows, microservices, and prototypes. A unified digital description integrates workflows and resource trees spanning IT and OT assets, connected via standards such as OPC UA, IEC 61131, and IEC 61499, and encapsulated through function blocks, skills, and behaviors. The architecture is semantically grounded by a semantic ontology and domain model, enabling both OLTP and OLAP use cases, asset administration shells (AAS), and interoperability across repositories and marketplaces. Overall, the framework formalizes the end-to-end transformation from semantic modeling to runtime orchestration, supporting scalable, interoperable, and self-descriptive industrial systems.